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pubmed-article:2705471pubmed:abstractTextWe have analysed the pedigrees of 265 probands with Crohn disease, collected from a specialty clinic at the University of Düsseldorf. Complex segregation analysis suggests the presence of a recessive gene with incomplete penetrance for susceptibility to the disease with no residual causes of family resemblance. However, a proportion of the isolated cases are probably due to phenocopies, this proportion being greatest among cases with an advanced age of onset.lld:pubmed
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pubmed-article:2705471pubmed:articleTitleThe genetics of Crohn disease: complex segregation analysis of a family study with 265 patients with Crohn disease and 5,387 relatives.lld:pubmed
pubmed-article:2705471pubmed:affiliationDepartment of Dermatology, University of Düsseldorf, Federal Republic of Germany.lld:pubmed
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