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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1989-5-19
|
| pubmed:abstractText |
We have analysed the pedigrees of 265 probands with Crohn disease, collected from a specialty clinic at the University of Düsseldorf. Complex segregation analysis suggests the presence of a recessive gene with incomplete penetrance for susceptibility to the disease with no residual causes of family resemblance. However, a proportion of the isolated cases are probably due to phenocopies, this proportion being greatest among cases with an advanced age of onset.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0148-7299
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
32
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
105-8
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2705471-Chromosome Mapping,
pubmed-meshheading:2705471-Crohn Disease,
pubmed-meshheading:2705471-Female,
pubmed-meshheading:2705471-Gene Frequency,
pubmed-meshheading:2705471-Genes, Recessive,
pubmed-meshheading:2705471-Germany, West,
pubmed-meshheading:2705471-Humans,
pubmed-meshheading:2705471-Male,
pubmed-meshheading:2705471-Models, Genetic,
pubmed-meshheading:2705471-Pedigree,
pubmed-meshheading:2705471-Phenotype
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
The genetics of Crohn disease: complex segregation analysis of a family study with 265 patients with Crohn disease and 5,387 relatives.
|
| pubmed:affiliation |
Department of Dermatology, University of Düsseldorf, Federal Republic of Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|