Linked Life Data

2702091

Source:http://linkedlifedata.com/resource/pubmed/id/2702091

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-11-20
pubmed:abstractText
Serum erythropoietin (Ep) levels were measured using a highly sensitive radioimmunoassay in 69 children undergoing chronic dialysis; 31 were anephric, whereas 38 were non-nephrectomized (nephric). Twenty-nine normal children were studied as controls. Serum Ep levels in the anephric group were much higher than anticipated (mean 19.7 +/- 1.8 mU/ml), albeit significantly lower than those measured in normal children (mean 26.2 +/- 2.4 mU/ml, P less than 0.05), or in nephric children on dialysis (33.0 +/- 2.9 mU/ml, P less than 0.001). Anephric children on peritoneal dialysis (PD) had significantly (P less than 0.05) higher serum levels of Ep (22.7 +/- 2.4 mU/ml, n = 19) than anephric children on hemodialysis (HD) (15.1 +/- 2.3 mU/ml, n = 12). There was no significant difference between Ep levels in anephric patients dialyzed for less than or equal to 1 year (19.6 +/- 2.0 mU/ml, n = 20) compared with anephric patients dialyzed for more than 1 year (20.0 +/- 3.9 mU/ml, n = 11). Although serum Ep levels showed a tendency to increase with time after nephrectomy, the mean values for less than 3 months (14.7 +/- 1.9), 3 months-12 months (21.0 +/- 2.7), and greater than 12 months (21.6 +/- 6.0) were not significantly different from each other. This demonstration of relatively normal levels of serum Ep in anephric children suggests that extrarenal sites of Ep production are able to exert a significant response to severe anemia in patients who are devoid of renal parenchyma.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0931-041X
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Measurement of erythropoietin in anephric children. A report of the Southwest Pediatric Nephrology Study Group.
pubmed:affiliation
Department of Pharmacology, Tulane University, School of Medicine, New Orleans, LA 70112.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.