Linked Life Data

2699453

Source:http://linkedlifedata.com/resource/pubmed/id/2699453

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-6-5
pubmed:abstractText
A nearly full length ME cDNA has been obtained and sequenced. The identity has been established by comparison of the translated nucleotide sequence with the amino acid sequence of 7 tryptic peptides from purified ME. Northern analysis with this cDNA shows that ME mRNA consists of two different messages of about 27S and 21S. The size difference between two ME mRNAs (approximately equal to 27S and 21S) is attributed to the differences in the 3' noncoding regions. The relative ratios of the two ME mRNAs differ in various tissues examined (liver, heart, kidney, brain, lung, spleen, and testis). Their regulation by T3 is tissue specific with coordinate stimulation of both mRNAs in liver, heart and kidney, suggesting a single promoter for both mRNAs and no stimulation of either in the other tissues. T3 regulates ME mRNA synthesis via a dual-tissue specific mechanism by increasing the rate of transcription in liver and heart and stabilizing nuclear ME RNA sequences only in liver.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0743-5800
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
547-64
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Coding nucleotide sequence of rat malic enzyme mRNA and tissue specific regulation by thyroid hormone.
pubmed:affiliation
Clinical Endocrinology Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.
pubmed:publicationType
Journal Article, Review