| pubmed-article:2699328 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2699328 | lifeskim:mentions | umls-concept:C0036126 | lld:lifeskim |
| pubmed-article:2699328 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:2699328 | lifeskim:mentions | umls-concept:C0039840 | lld:lifeskim |
| pubmed-article:2699328 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:2699328 | lifeskim:mentions | umls-concept:C0178793 | lld:lifeskim |
| pubmed-article:2699328 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:2699328 | lifeskim:mentions | umls-concept:C1611588 | lld:lifeskim |
| pubmed-article:2699328 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:2699328 | pubmed:dateCreated | 1990-5-29 | lld:pubmed |
| pubmed-article:2699328 | pubmed:abstractText | The herbicide suphometuron methyl inhibits the utilization of pyruvate and 2-ketobutyrate by the branched-chain amino acid biosynthetic enzyme acetolactate synthase. Eighteen insertions of the transposon Tn10 into the genome of Salmonella typhimurium LT2 caused hypersensitivity to this herbicide. Five of these insertions conferred a partial auxotrophic requirement. Concurrent herbicide sensitivity and heat-labile pantothenate auxotrophy was due to panD::Tn10 mutations, while coincident sulphometuron methyl sensitivity and thiamin auxotrophy was attributable to thiA::Tn10 mutations. The phenotypes of these mutations suggested that coenzyme A and thiamin pyrophosphate availability modulated the cells' response to sulphometuron methyl. A model suggesting a key role for 2-ketobutyrate accumulation in herbicide action is supported by the function of thiamin pyrophosphate in 2-ketoacid metabolism and the known role of a 2-ketoacid in coenzyme A synthesis. | lld:pubmed |
| pubmed-article:2699328 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2699328 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2699328 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2699328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2699328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2699328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2699328 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2699328 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2699328 | pubmed:issn | 0022-1287 | lld:pubmed |
| pubmed-article:2699328 | pubmed:author | pubmed-author:LaRossaR ARA | lld:pubmed |
| pubmed-article:2699328 | pubmed:author | pubmed-author:Van DykT KTK | lld:pubmed |
| pubmed-article:2699328 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2699328 | pubmed:volume | 135 | lld:pubmed |
| pubmed-article:2699328 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2699328 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2699328 | pubmed:pagination | 2209-22 | lld:pubmed |
| pubmed-article:2699328 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2699328 | pubmed:meshHeading | pubmed-meshheading:2699328-... | lld:pubmed |
| pubmed-article:2699328 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2699328 | pubmed:articleTitle | Leaky pantothenate and thiamin mutations of Salmonella typhimurium conferring suphometuron methyl sensitivity. | lld:pubmed |
| pubmed-article:2699328 | pubmed:affiliation | Central Research and Development Department, E. I. du Pont de Nemours and Company, Wilmington, DE 19880-0328. | lld:pubmed |
| pubmed-article:2699328 | pubmed:publicationType | Journal Article | lld:pubmed |
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