Linked Life Data

2698601

Source:http://linkedlifedata.com/resource/pubmed/id/2698601

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-5-1
pubmed:abstractText
The genetic systems developed in the mould Aspergillus nidulans to study the chemical induction of mitotic genetic segregation were used to investigate the mechanism of aneuploidy induction by the main benzene hydroxy metabolites. Detailed genetic analysis of mitotic segregants produced by individual colonies revealed the simultaneous occurrence of both whole chromosome segregants and mitotic cross-overs, i.e. a pattern not compatible with the induction of numerical abnormalities as the primary event. Confirmatory evidence was obtained in a haploid strain, thus demonstrating the possible secondary origin of aneuploidy following the induction of structural chromosome damages. Furthermore, mutagenic, lethal and growth-arresting properties of a series of chlorinated hydrocarbons were quantitatively estimated and compared to a series of physico-chemical descriptors of the molecules to assess the possible role of unspecific physical interactions in their mechanism of action. The analysis of the interrelationships among these variables highlighted a possible correlation among physico-chemical descriptors and toxic properties and a dissociation of the aneugenic activity with the other chemical and biological descriptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0021-2571
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
563-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Aspergillus nidulans as a test organism for the detection of chemically-induced mitotic crossing-over and chromosome malsegregation.
pubmed:publicationType
Journal Article, In Vitro