Linked Life Data

2698018

Source:http://linkedlifedata.com/resource/pubmed/id/2698018

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-4-13
pubmed:abstractText
The authors found there was behavioral sensitization induced by repeated intermittent treatments with beta-phenylethylamine (PEA), an endogenous trace amine, similar to the so-called reverse-tolerance phenomenon which persists long after the withdrawal. A series of behavioropharmacological and neurochemical studies on the PEA-sensitized rats were compared with that on the sensitization induced by amphetamines (AMP). The major portion of this review focused on an involvement of dopaminergic modifications in the reverse tolerance caused by both PEA and AMP. The enhanced stereotype in the PEA-sensitized rats was found to be accompanied by augmentation of presynaptic dopaminergic activity in nigrostriatal and mesocorticolimbic systems by means of regional dissected and in vivo dialysis methods. In particular, a simultaneous measurement of endogenous PEA levels in striatum led us to speculate that the DA terminals in sensitized animals are hyperresponsive to PEA, resulting in enhanced DA release. D2 receptor bindings in nucleus accumbens, not in striatum, also altered in PEA-sensitized rats. In addition, recent literature concerning changes in PEA levels in body fluids in psychiatric disorders are summarized. Lastly, the attractive reports regarding the possibility that central actions of AMP would be mediated by endogenous PEA and that PEA is co-localized with DA in the same neurons were reviewed, suggesting an important role of endogenous PEA in generating the psychostimulant-induced and endogenous psychosis.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0285-5313
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
335-48
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
[beta-Phenylethylamine and amphetamine: similar aspects in their behavioropharmacological and neurochemical characteristics].
pubmed:affiliation
Laboratory of Neurochemistry, Hizen National Mental Hospital, Saga, Japan.
pubmed:publicationType
Journal Article, Comparative Study, English Abstract, Review