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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1990-3-16
|
| pubmed:abstractText |
The development from the discovery of the structure of cholesterol, the precursor of all steroids, to the first application of a topically effective steroid in 1952 took about 20 years. Thereafter the development of more potent topically effective steroids accelerated and the third generation of potent steroids with a topical activity of about 10 to 20 times that of hydrocortisone was already available about 10 years later. Today the newly developed non-fluorinated non-symmetric 16 alpha, 17 alpha-acetal derivate budesonide could perhaps be considered as the sixth generation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0365-8341
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
151
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4-6; discussion 47-52
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading | |
| pubmed:year |
1989
|
| pubmed:articleTitle |
The history of corticosteroids.
|
| pubmed:affiliation |
Blackmore Partners, Shaftesbury, UK.
|
| pubmed:publicationType |
Journal Article,
Historical Article
|