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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2-3
|
pubmed:dateCreated |
1990-3-19
|
pubmed:abstractText |
Removal of the epithelium increased the responsiveness of isolated guinea-pig trachea to the contractile effects of endothelin. This phenomenon was observed in the presence of indomethacin (5 microM), captopril (10 microM), bacitracin (20 micrograms/ml) or leupeptin (50 microM), but was inhibited by phosphoramidon (10 microM). Bacitrain enhanced contraction produced by endothelin. The increased responsiveness of denuded guinea-pig trachea to endothelin may be due to removal of an epithelium-derived phosphoramidon-sensitive peptidase.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0014-2999
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
21
|
pubmed:volume |
171
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
241-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2695340-Animals,
pubmed-meshheading:2695340-Endothelins,
pubmed-meshheading:2695340-Epithelium,
pubmed-meshheading:2695340-Guinea Pigs,
pubmed-meshheading:2695340-Male,
pubmed-meshheading:2695340-Muscle, Smooth,
pubmed-meshheading:2695340-Muscle Contraction,
pubmed-meshheading:2695340-Peptides,
pubmed-meshheading:2695340-Protease Inhibitors,
pubmed-meshheading:2695340-Trachea
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pubmed:year |
1989
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pubmed:articleTitle |
Guinea-pig tracheal epithelium and endothelin.
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pubmed:affiliation |
Department of Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939.
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pubmed:publicationType |
Journal Article,
In Vitro
|