Linked Life Data

2692457

Source:http://linkedlifedata.com/resource/pubmed/id/2692457

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6 Pt 1
pubmed:dateCreated
1990-2-12
pubmed:abstractText
There has been recent evidence that the liver through the hepatic vagus nerve may influence the resting levels of plasma insulin in adrenalectomized rats. The present investigation was designed to evaluate whether such a relationship exists during physical exercise. To this end, the effects of a selective hepatic vagotomy on portal and peripheral insulin and on peripheral glucagon concentrations were studied after a 30-min treadmill run (26 m/min, 0% grade) in adrenodemelludated rats. Hepatic vagotomy was associated with small but significantly higher (P less than 0.05) levels of liver glycogen and blood glucose at rest and after exercise. No significant differences were observed between hepatic-vagotomized and sham-operated rats in resting insulin, glucagon, and plasma norepinephrine concentrations. Peripheral plasma insulin levels after exercise were significantly higher (P less than 0.01) in hepatic-vagotomized than in sham-operated rats [172 +/- 20 vs. 108 +/- 10 (SE) pmol/l]. Exercise was also associated with a significantly lower peripheral glucagon (P less than 0.01) and norepinephrine (P less than 0.05) levels in hepatic-vagotomized compared with sham-operated rats. These results indicate a role for the hepatic vagus nerve in the regulation of pancreatic islet secretion during exercise, possibly by contributing to the increase in sympathetic activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
257
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
E855-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Influence of hepatic vagus nerve on pancreatic hormone secretion during exercise.
pubmed:affiliation
Départment d'Education Physique, Université de Montréal, Quebec, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't