Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-2-22
pubmed:abstractText
Vascular endothelium is now known to produce a vasodilator agent, known as endothelium derived relaxing factor (EDRF) and recently shown to be nitric oxide. It acts locally on subjacent vascular smooth muscle by stimulating soluble guanylate cyclase to increase cyclic GMP levels and so reduce cytosolic free calcium. EDRF activity varies widely between different artery types and can be stimulated by various pharmacological agents and by flow. Studies in the intact vascular bed of the buffer-perfused rabbit ear show that EDRF activity is high in resistance vessels (particularly those of ca. 150 microns diameter), that EDRF is responsible for a 4th power relationship of diameter to flow in response to acute changes in flow (so limiting pressure gradients needed to increase flow rate), and that basal EDRF activity maintains geometric similarity of vessel diameters (implying that the spatial distribution of flow remains constant at different flow rates).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0167-6865
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
383-96
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
EDRF and the regulation of vascular tone.
pubmed:affiliation
Department of Radiology, University of Wales College of Medicine, Health Park, Cardiff, United Kingdom.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't