Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-1-23
pubmed:abstractText
These data from in vitro studies, partially confirmed on intact glomeruli, suggest that glomerular cells are not only responsive to a number of growth-regulatory peptides but they are also important sources of several of these agents. The studies on transgenic mice confirm the potential role of the insulin-like peptides. This model also provides clear evidence that genetically directed modifications of cell behavior are important in the pathogenesis of glomerulosclerosis. The ability of glomerular cells to undergo proliferation and participate in hypertrophy of the glomerulus may be a critical determinant in the development of progressive glomerulosclerosis. That this ability is controlled by genetic differences between species and individuals seems well-established in both animal studies and clinical experience.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0270-9295
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
318-28
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
The contribution of glomerular mesangial cells to progressive glomerulosclerosis.
pubmed:affiliation
Renal Cell Biology Unit, NIDDK, Bethesda, MD 20892.
pubmed:publicationType
Journal Article, Review