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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1990-1-2
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pubmed:abstractText |
Treatment of rabbit aortic endothelial cells or human umbilical vein cells for as little as 1 day with 25 micrograms/ml of beta-migrating very low density lipoprotein (beta-VLDL), but not low density lipoprotein (LDL), caused an increased binding of human peripheral blood monocytes to the endothelium. This increase was maximal by 24 hours but was not significant at 4 hours of pre-incubation with beta-VLDL. Neutrophil binding was not significantly stimulated by beta-VLDL treatment of endothelial cells, while endotoxin (LPS) treatment of endothelial cells stimulated both neutrophil and monocyte binding. Antibody to leukocyte function-associated-antigen-1 and to Mo2 inhibited binding to both beta-VLDL-stimulated and LPS-stimulated cells by 25%. The fact that both rabbit and human cells were stimulated by beta-VLDL to bind human monocytes suggests that some mechanisms regulating binding are conserved between species. These studies suggest that beta-VLDL acts like a chronic inflammatory mediator to cause a sustained increase in binding of monocytes to the endothelium.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, VLDL,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Function-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Leukocyte-Adhesion
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pubmed:status |
MEDLINE
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pubmed:issn |
0276-5047
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
824-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2686605-Animals,
pubmed-meshheading:2686605-Antigens, Differentiation,
pubmed-meshheading:2686605-Cell Adhesion,
pubmed-meshheading:2686605-Endothelium, Vascular,
pubmed-meshheading:2686605-Humans,
pubmed-meshheading:2686605-Immunologic Techniques,
pubmed-meshheading:2686605-Lipoproteins, LDL,
pubmed-meshheading:2686605-Lipoproteins, VLDL,
pubmed-meshheading:2686605-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:2686605-Monocytes,
pubmed-meshheading:2686605-Neutrophils,
pubmed-meshheading:2686605-Rabbits,
pubmed-meshheading:2686605-Receptors, Leukocyte-Adhesion,
pubmed-meshheading:2686605-Time Factors
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pubmed:articleTitle |
Beta-very low density lipoprotein pretreatment of endothelial monolayers increases monocyte adhesion.
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pubmed:affiliation |
Department of Medicine, University of California Los Angeles School of Medicine 90024.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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