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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1977-10-14
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pubmed:abstractText |
A significant correlation has been found in man between total daily cholesterol synthesis rates as determined by sterol balance measurements and the fraction of intravenously administered R-[5-14C]mevalonic acid converted to cholesterol. In 30 studies it was found that the mean daily cholesterol synthesis rates estimated by sterol balance measurements ranged from 395 to 3047 mg/day, whereas the fractional conversion of mevalonate to cholesterol varied from 0.28 to 0.99. The two parameters correlated with a coefficient of 0.87, P less than 0.001. This method for estimating cholesterol synthesis rates requires low doses of radioisotopic materials (25 muCi of [14C]mevalonate and 5 muCi of [3H]cholesterol) and less than 1 hr of the patient's time; it can be repeated at intervals of 3 weeks and reflects cholesterol synthesis over a short period of time.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/268653-1060141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/268653-1112830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/268653-14340676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/268653-16695935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/268653-191001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/268653-4698266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/268653-4698267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/268653-4811213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/268653-5393333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/268653-5569253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/268653-5646188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/268653-5764121
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3043-6
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pubmed:dateRevised |
2010-9-2
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pubmed:meshHeading |
pubmed-meshheading:268653-Adult,
pubmed-meshheading:268653-Aged,
pubmed-meshheading:268653-Cholesterol,
pubmed-meshheading:268653-Cholestyramine Resin,
pubmed-meshheading:268653-Female,
pubmed-meshheading:268653-Humans,
pubmed-meshheading:268653-Kinetics,
pubmed-meshheading:268653-Male,
pubmed-meshheading:268653-Mevalonic Acid,
pubmed-meshheading:268653-Middle Aged,
pubmed-meshheading:268653-Squalene
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pubmed:year |
1977
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pubmed:articleTitle |
Measurement of daily cholesterol synthesis rates in man by assay of the fractional conversion of mevalonic acid to cholesterol.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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