Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1990-1-11
pubmed:abstractText
Human malignant melanomas, unlike normal melanocytes, can proliferate in the absence of exogenous basic fibroblast growth factor (bFGF). Exposure of primary melanomas in the vertical growth phase and metastatic melanomas to antisense oligodeoxynucleotides targeted against three different sites of human bFGF mRNA inhibited cell proliferation and colony formation in soft-agar. In contrast, exposure of human bFGF sense or antisense oligonucleotides complementary to human beta-nerve growth factor or insulin-like growth factor I mRNA had no such effects. These experiments indicate that activation of the bFGF gene may play an important role in the progression from melanocytic precursor lesions to malignant melanoma.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-2425435, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-2433691, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-2459134, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-2461309, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-2461588, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-2541433, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-2541445, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-2839841, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-2897717, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-2953031, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-2957062, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-3012555, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-3013624, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-3027025, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-3041414, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-3043199, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-3211147, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-3226725, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-3277186, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-3280975, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-3316051, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-3330780, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-3401023, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-3459165, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-3475697, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-3553733, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-3699806, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-3780670, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-3901002, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-3940171, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-3964923, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-4053039, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-6093111, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-6500548, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-6584203, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-6688123, http://linkedlifedata.com/resource/pubmed/commentcorrection/2684645-945805
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3685-91
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Proliferation of human malignant melanomas is inhibited by antisense oligodeoxynucleotides targeted against basic fibroblast growth factor.
pubmed:affiliation
Department of Tumor Biology, M.D. Anderson Cancer Center, Houston, TX 77030.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.