Linked Life Data

2683851

Source:http://linkedlifedata.com/resource/pubmed/id/2683851

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-11-28
pubmed:abstractText
It was the aim of present study to examine possible interactions between human growth hormone (hGH) and Somatomedin C (SmC), when inducting anaesthesia with propofol in healthy patients. Moreover these effects of propofol should be compared with that of diazepam and thiopentone. 30 patients scheduled for elective plastic-surgery were divided randomly into 3 groups. Induction of anaesthesia was performed in group 1 with diazepam, in group 2 with thiopentone and in group 3 with propofol. Measurements of hGH, SmC as well as blood glucose were performed at 4 different given times: (1.) preoperatively, (2.) 15 minutes, (3.) 30 minutes, (4.) 60 minutes after inducting anaesthesia. Diazepam and thiopentone lead to increases in hGH secretion already in a very early phase after induction of anesthesia (15 minutes) and remained on elevated level. Concentrations of Somatomedin C, as well as of blood glucose, however, remained unchanged during the whole observation period. In comparison to that findings propofol did not show any influence on hGH and consecutively on Somatomedin C activity at any time. Based on our results we can conclude that propofol should be the induction-agent of choice predominantly when anaesthetizing patients with unknown hormonal state (outpatients scheduled for operation).
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0174-1837
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
226-30
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
[The behavior of hGH (human growth hormone) and somatomedin C following anesthesia induction with propofol in comparison with diazepam and thiopental].
pubmed:affiliation
Klinik für Anaesthesie und Allgemeine Intensivmedizin, Universität Innsbruck.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, English Abstract, Randomized Controlled Trial