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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1989-12-7
|
| pubmed:abstractText |
The effect of perioperative blood transfusion on disease-free and overall survival was studied in 812 patients with stages I and II breast cancer, followed up prospectively in a multicenter study. All patients initially underwent a modified radical mastectomy. Patients with axillary node-negative, stage I cancer were followed up without additional therapy. Patients with axillary node-positive, stage II cancer were randomized to receive adjuvant chemoendocrine therapy. Transfusion was done in 35.8% of the patients with stage I and in 37.3% of the patients with stage II cancer. For the patients with stage II cancer, perioperative blood transfusion did not affect disease-free or overall survival. For the patients with stage I cancer, perioperative blood transfusion resulted in a worse disease-free and overall survival (p = 0.05 and 0.02, respectively), which was particularly evident for those patients who received more than 1 unit. This study suggests that stage of disease, adjuvant therapy, number of transfusions, and duration of follow-up must be considered in further analyses.
|
| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0039-6060
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
106
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
836-41
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2683172-Actuarial Analysis,
pubmed-meshheading:2683172-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:2683172-Axilla,
pubmed-meshheading:2683172-Blood Transfusion,
pubmed-meshheading:2683172-Breast Neoplasms,
pubmed-meshheading:2683172-Combined Modality Therapy,
pubmed-meshheading:2683172-Evaluation Studies as Topic,
pubmed-meshheading:2683172-Female,
pubmed-meshheading:2683172-Follow-Up Studies,
pubmed-meshheading:2683172-Humans,
pubmed-meshheading:2683172-Lymphatic Metastasis,
pubmed-meshheading:2683172-Mastectomy, Modified Radical,
pubmed-meshheading:2683172-Multicenter Studies as Topic,
pubmed-meshheading:2683172-Neoplasm Staging,
pubmed-meshheading:2683172-Prognosis,
pubmed-meshheading:2683172-Prospective Studies,
pubmed-meshheading:2683172-Random Allocation,
pubmed-meshheading:2683172-Time Factors
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Breast cancer survival and perioperative blood transfusion.
|
| pubmed:affiliation |
Department of Surgery, Case Western Reserve University, Cleveland, Ohio.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Multicenter Study
|