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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1989-12-14
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pubmed:abstractText |
Duplication-containing cells are selected when growth of Salmonella typhimurium is limited by the availability of any one of several carbon and energy sources. Under conditions of extreme starvation, growth occurs almost exclusively in the duplication-containing fraction of the population. Cells with duplications of one large segment of the chromosome are repeatedly selected regardless of which of these carbon sources limits growth. The duplicated chromosomal segment encodes the transport systems for all of these carbon sources. This duplication is not selected during growth on a carbon source for which the permease is not included within the duplication segment. This suggests that the growth advantage conferred by the duplication may be due to increased transport of the limiting carbon source. Inclusion of the permease alone is not sufficient to explain the growth advantage of the duplications, since other common duplications that include the permease are not selected.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-1102715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-13278318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-14808160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-3070321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-334045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-360995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-4564719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-4565618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-4874308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-4950180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-6086936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-6094484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-6263754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-6283309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-6308409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-6327052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-6327606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-6348472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-6370963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-6627396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2680755-7012118
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0016-6731
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
19-28
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2680755-Adaptation, Physiological,
pubmed-meshheading:2680755-Arabinose,
pubmed-meshheading:2680755-Carbon,
pubmed-meshheading:2680755-Chromosome Mapping,
pubmed-meshheading:2680755-Culture Media,
pubmed-meshheading:2680755-Multigene Family,
pubmed-meshheading:2680755-Salmonella typhimurium,
pubmed-meshheading:2680755-Selection, Genetic,
pubmed-meshheading:2680755-Sorbitol,
pubmed-meshheading:2680755-Transduction, Genetic
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pubmed:year |
1989
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pubmed:articleTitle |
Role of gene duplications in the adaptation of Salmonella typhimurium to growth on limiting carbon sources.
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pubmed:affiliation |
Department of Biology, University of Utah, Salt Lake City 84112.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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