Linked Life Data

2680668

Source:http://linkedlifedata.com/resource/pubmed/id/2680668

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-12-4
pubmed:abstractText
The short term effects of ovine placental lactogen and progesterone have been studied on skeletal muscle glucose metabolism in order to determine their respective roles in pregnancy-induced insulin resistance. The rates of hexose transport, glycogen synthesis, and glycolysis were measured in vitro by incubating stretched soleus, extensor digitorum longus (EDL) and epitrochlearis from virgin rats. When incubated in plasma from late pregnant rats, EDL glucose metabolism was reduced by 30% when compared to EDL incubated in plasma from virgin rats despite similar glucose (8 mM) and insulin (200 microU/ml) concentrations. Ovine placental lactogen (5 X 10(-7) M) had no effect on EDL glucose metabolism either in the basal state or after stimulation by insulin (100 microU/ml). Progesterone (10(-4) M) induced an inhibition of hexose transport, glycogen synthesis and glycolysis rates up to 60% in the absence or in the presence of insulin in all muscles studied. In conclusion, the plasma of late pregnant rats contains factors responsible for a decreased rate of glucose metabolism in incubated skeletal muscle. This is mimicked by progesterone but not by ovine placental lactogen added to the incubation medium.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0338-1684
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
176-81
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:articleTitle
Effects of placental lactogen and progesterone on insulin stimulated glucose metabolism in rat muscles in vitro.
pubmed:affiliation
Centre de Recherches sur la Nutrition, CNRS, Meudon-Bellevue.
pubmed:publicationType
Journal Article, In Vitro