Linked Life Data

2679765

Source:http://linkedlifedata.com/resource/pubmed/id/2679765

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1989-11-27
pubmed:abstractText
In both the central and the peripheral nervous systems, impulse activity regulates the expression of a vast number of genes that code for synaptic proteins, including neuropeptides, enzymes involved in neurotransmitter biosynthesis and degradation, and membrane receptors. In recent years, the mechanisms involved in these regulations became amenable to investigation by the methods of recombinant DNA technology. The first part of this review focuses on the activity-dependent control of nicotinic acetylcholine receptor biosynthesis in vertebrate muscle, a model case for the regulation of synaptic protein biosynthesis at the postsynaptic level. The second part summarizes some examples of neuronal proteins whose biosynthesis is under the control of transsynaptic impulse activity. The first, second, and third intracellular messengers involved in membrane-to-gene signaling are discussed, as are possible posttranscriptional control mechanisms. Finally, models are proposed for a role of neuronal activity in the genesis and stabilization of the synapse.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0893-7648
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-53
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Activity-dependent regulation of gene expression in muscle and neuronal cells.
pubmed:affiliation
URA, CNRS 0210 Département des Biotechnologies, Institut PASTEUR, Paris, France.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't