Linked Life Data

2679494

Source:http://linkedlifedata.com/resource/pubmed/id/2679494

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1989-11-8
pubmed:abstractText
Adrenergic regulation of lipid metabolism is mediated by various intracellular messengers, including calcium ions. Little is known about the role of calcium in the catabolism of triglyceride-rich lipoproteins. Aim of this study was to investigate whether blockade of calcium influx across the cell membrane influences lipid metabolism in man. The calcium entry blocker nitrendipine was administered to 10 hypertensive, normolipidemic subjects for eight weeks at the dose of 10 mg b.i.d. An enhancement in plasma clearance of triglyceride was observed after nitrendipine administration: fractional removal rate of the triglyceride emulsion Intralipid increased by 22% (from 3.13 +/- 1.1 after placebo to 3.81 +/- 1.4% min after nitrendipine, p less than 0.03). Fasting serum triglyceride was not shifted (83 +/- 57 vs 84 +/- 37 mg/dl). Total serum cholesterol and cholesterol in high density lipoproteins were also unchanged during the study. No evidence of change in insulin response was detected. It is hypothesized that calcium plays a role in the modulation of lipoprotein lipase, the enzyme mainly responsible of the removal of exogenous triglyceride from plasma. Alternatively, the increase in the clearance rate of the triglyceride emulsion might be explained by the vasodilating activity of nitrendipine.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0098-6127
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
312-26
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Enhancement of exogenous triglyceride removal following calcium channel blockade.
pubmed:affiliation
Institute of Internal Medicine and Metabolic Diseases 2nd Medical School, University of Naples, Italy.
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial