Linked Life Data

2679108

Source:http://linkedlifedata.com/resource/pubmed/id/2679108

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-11-21
pubmed:abstractText
An in vitro recycled perfusion of the human placenta was used to investigate the effect of insulin on placental metabolism and transfer of glucose. Human insulin, 1000 microU/ml, was introduced into either maternal or maternal and fetal compartments. In one series of experiments placentas were used as either a control group or study group, whereas in the other series each placenta served as its own control. Metabolic effects were determined by measuring placental glucose and oxygen consumption and lactate production rate. The effect of insulin on transfer was studied by the use of 3-O-methylglucose labeled with tritium; this effect was expressed as the slope of maternal minus fetal concentrations on a natural logarithmic scale and compared with the antipyrine tagged with carbon 14. The stability of perfusate volume was used as an index for placental integrity, whereas absence of tissue edema demonstrated adequacy of perfusion. Neither of the metabolic parameters studied was significantly affected by insulin, and insulin did not have an effect on 3-O-methylglucose transfer rate. It was concluded that, in contrast to other tissues in the body, placental glucose metabolism and transfer are not sensitive to the action of insulin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0002-9378
pubmed:author
pubmed:issnType
Print
pubmed:volume
161
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
953-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Does insulin affect placental glucose metabolism and transfer?
pubmed:affiliation
Department of Obstetrics and Gynecology A, Rambam Medical Center, Haifa, Israel.
pubmed:publicationType
Journal Article