Linked Life Data

2678033

Source:http://linkedlifedata.com/resource/pubmed/id/2678033

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-11-1
pubmed:abstractText
Immunohistochemical staining analysis of oral lichen planus (OLP) using monoclonal antibodies (MoAbs) against the components of basement membrane (BM) and infiltrated cells was performed in 27 cases. Integrity of lining epithelial BM was more strictly elucidated by staining for laminin and type IV collagen than by fibronectin. Staining patterns of laminin were similar to type IV collagen. In the cases examined, continuity of BM was proven by laminin staining in 10 cases, partially destructive BM was seen in 9 cases and complete destruction of BM in 8 cases. Dividing OLP into 20 symptomatic (ulcerative/erosive) and 7 asymptomatic (non-ulcerative/-erosive) cases, intact BM could be observed in only 5 cases of the symptomatic group, while 5 cases of the other group possessed undamaged BM. The difference between the two groups was significant. Stromal and epidermal cell infiltrates, which were mainly composed of T cell subsets with accompanying Leu-M5 and 6-positive cells, were correlated with the condition of BM. Stromal Leu-M5+ and Leu-6+ cell infiltrates were clearly more dominant in laminin-negative (BM-destructed) cases than infiltrates in BM-intact cases. This relation was also found in epidermal infiltrates with the same manner of Leu-4 infiltration. From the above, it seems that the integrity of BM is concerned with cell infiltrates and clinical manifestations of OLP.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0344-0338
pubmed:author
pubmed:issnType
Print
pubmed:volume
185
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
218-24
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Destruction of basement membrane and cell infiltrates in oral lichen planus.
pubmed:affiliation
Department of Oral Surgery, Kochi Medical School, Japan.
pubmed:publicationType
Journal Article