Linked Life Data

2675861

Source:http://linkedlifedata.com/resource/pubmed/id/2675861

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-11-9
pubmed:abstractText
Four criteria should be fulfilled when establishing an animal model of alcoholism. (1) The animal should voluntarily and selectively consume a solution of the drug to yield pharmacologically significant blood alcohol concentrations. When ethanol is consumed for several weeks under these conditions, (2) the animals should exhibit tolerance to the acute effects of the drug. Furthermore, (3) abrupt termination of drug administration should result in physical signs of drug withdrawal (e.g. audiogenic seizures). (4) Changes in endocrine and liver function would also be expected to occur following the chronic administration of alcohol, such effects being particularly pronounced if the diet of the animal is nutritionally deficient. A number of self-administration, operant conditioning and forced alcohol administration models are critically assessed. A detailed description of the models in which rodents are forced to consume increasing quantities of alcohol as part of a nutritionally enriched milk diet suggests that this method fulfils most of the above criteria.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0735-0414
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
299-309
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Rodent models of alcoholism: a review.
pubmed:affiliation
Department of Pharmacology, University College, Galway, Republic of Ireland.
pubmed:publicationType
Journal Article, Review