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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
1989-10-24
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pubmed:databankReference |
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pubmed:abstractText |
Four genes encoding bombyxin have been located in a 14-kilobase Bombyx genomic DNA segment. All of these genes encode preprobombyxin, the precursor molecule for bombyxin, with the domain organization of signal peptide/B chain/C peptide/A chain. Bombyxins are classified as family A or B according to their sequence homology. Two genes, each belonging to a different family, are closely apposed to form a pair with opposite orientation, presumably forming a regulatory unit for transcription. Genomic Southern blot hybridization suggested that there are many such gene pairs in the Bombyx genome. Differences between bombyxin genes and vertebrate insulin-family genes indicate that different mechanisms operate in the evolution of invertebrate and vertebrate insulin-family genes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-16593744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-17832633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-2708384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-2821358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-2986538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-3023635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-3049291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-3301403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-3340203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-3909947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-3963370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-4059056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-472755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-503234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-6235151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-6279311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-6397124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-6817923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-7460015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2674935-911786
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6843-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2674935-Amino Acid Sequence,
pubmed-meshheading:2674935-Animals,
pubmed-meshheading:2674935-Base Sequence,
pubmed-meshheading:2674935-Blotting, Northern,
pubmed-meshheading:2674935-Blotting, Southern,
pubmed-meshheading:2674935-Bombyx,
pubmed-meshheading:2674935-Cloning, Molecular,
pubmed-meshheading:2674935-Genes,
pubmed-meshheading:2674935-Insect Hormones,
pubmed-meshheading:2674935-Insulin,
pubmed-meshheading:2674935-Molecular Sequence Data,
pubmed-meshheading:2674935-Multigene Family,
pubmed-meshheading:2674935-Oligonucleotide Probes,
pubmed-meshheading:2674935-Protein Sorting Signals,
pubmed-meshheading:2674935-Restriction Mapping,
pubmed-meshheading:2674935-Sequence Homology, Nucleic Acid
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pubmed:year |
1989
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pubmed:articleTitle |
Structure and organization of four clustered genes that encode bombyxin, an insulin-related brain secretory peptide of the silkmoth Bombyx mori.
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pubmed:affiliation |
Biological Institute, Faculty of Science, Nagoya University, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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