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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1989-10-26
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pubmed:abstractText |
Twenty successive adult patients with lymphoblastic lymphoma entered a study of sequential chemotherapy consisting of an intensive LSA2-L2-type protocol to induce first complete remission. Twelve patients in first CR (median age 22 years, range 15-43), after receiving a conditioning regimen consisting of cyclophosphamide and total body irradiation, underwent autologous bone marrow transplantation. Of these 12 patients at diagnosis, one was in stage III and 11 in stage IV; 11 showed mediastinal and seven showed bone marrow involvement. The transplant procedure was well tolerated and no treatment-induced deaths occurred. At this time nine patients are alive and well 25-44 months post-transplant (median follow-up 36 months) with an actuarial disease-free survival of 75%. These early results suggest that high-dose chemoradiotherapy followed by autologous bone marrow transplantation may improve long-term disease-free survival in advanced stage adult lymphoblastic lymphoma. In order to draw definite conclusions, however, a larger and randomized study is needed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0268-3369
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
399-404
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:2673460-Adolescent,
pubmed-meshheading:2673460-Adult,
pubmed-meshheading:2673460-Bone Marrow Transplantation,
pubmed-meshheading:2673460-Cell Survival,
pubmed-meshheading:2673460-Cyclophosphamide,
pubmed-meshheading:2673460-Female,
pubmed-meshheading:2673460-Humans,
pubmed-meshheading:2673460-Lymphoma, Non-Hodgkin,
pubmed-meshheading:2673460-Male,
pubmed-meshheading:2673460-Neoplasm Staging,
pubmed-meshheading:2673460-Pilot Projects,
pubmed-meshheading:2673460-Remission Induction,
pubmed-meshheading:2673460-Transplantation, Autologous,
pubmed-meshheading:2673460-Whole-Body Irradiation
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pubmed:year |
1989
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pubmed:articleTitle |
Autologous bone marrow transplantation for advanced stage adult lymphoblastic lymphoma in first complete remission. A pilot study of the non-Hodgkin's Lymphoma Co-operative Study Group (NHLCSG).
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pubmed:affiliation |
Division of Hematology, Ospedale S. Martino, Genoa, Italy.
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pubmed:publicationType |
Journal Article
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