Linked Life Data

2673316

Source:http://linkedlifedata.com/resource/pubmed/id/2673316

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-10-17
pubmed:abstractText
1. The antihypertensive efficacy of a long acting formulation of the calcium channel blocking drug, nicardipine, was assessed using clinic and ambulatory (Remler M2,000) blood pressure measurements. 2. Eleven patients with essential hypertension (mean +/- s.e. mean; 173 +/- 6.6/103 +/- 1.9 mmHg) completed a randomised double-blind, placebo-controlled, cross-over study. The dose of nicardipine used was 60 mg twice daily for 4 weeks. 3. Mean ambulatory blood pressure was reduced from 164 +/- 5.3/97 +/- 2.9 to 151 +/- 5.2/88 +/- 2.4 mmHg (P less than 0.01); this effect was shown to be sustained for 8 h after the morning dose. Mean ambulatory heart rate was not significantly affected by treatment. 4. Clinic lying systolic blood pressure was reduced on treatment from 169 +/- 7.1 to 157 +/- 5.9 mmHg (P less than 0.2) and diastolic blood pressure from 99 +/- 3.6 to 89 +/- 3.9 mmHg (P less than 0.05). 5. One patient was withdrawn because of dizziness and flushing while on nicardipine; vasodilatory side effects such as headache, palpitations and flushing on nicardipine were noted by three patients. 6. We conclude that the long acting formulation of nicardipine studied in a dose of 60 mg twice daily is effective as monotherapy and is relatively well tolerated in mild hypertension. 7. This study highlights the importance of ambulatory blood pressure measurement in detecting significant changes in blood pressure, thereby permitting the study of small numbers of patients.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2673316-2418302, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673316-3092951, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673316-3280674, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673316-3429863, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673316-3896278, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673316-3940158, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673316-3965774, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673316-552299, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673316-6502496, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673316-6527979, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673316-6681029, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673316-6749700, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673316-7171405, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673316-7332733, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673316-881279
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0306-5251
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
79-82
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
The effect of slow-release nicardipine on ambulatory and clinic blood pressure in mild hypertension.
pubmed:affiliation
Blood Pressure Clinic, Beaumont Hospital, Dublin, Ireland.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't