Linked Life Data

2673083

Source:http://linkedlifedata.com/resource/pubmed/id/2673083

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-10-6
pubmed:abstractText
One hundred thirty-one consecutive infants with biliary atresia were operated on during the 15-year period between 1973 and 1988. Six patients did not have biliary reconstruction because of advanced cirrhosis or transplant preference. The other 125 infants had excision of all nonpatent extrahepatic bile ducts; biliary drainage was provided by a gallbladder-common bile duct conduit in 14 patients and by a Roux-en-Y portoenterostomy in 111 infants (including the seven patients with correctable biliary atresia). The bilioenteric conduit was temporarily exteriorized and, for the past 2 years, a conduit intussusception valve was incorporated. Immediate postsurgical bile drainage was achieved in 103 infants (82%). Reoperation during the first 6 postoperative weeks restored bile flow in 14 of 18 infants who had shut down. Seventy-two patients (57%) had sustained (more than 1 year) relief of biliary obstruction. Postoperative morbidity was substantial. The six children not having corrective surgery died within 19 months. Three patients were lost to follow-up. Sixty-eight patients having Kasai's operation died, 55 from complications of liver disease, 1 from a coexisting malformation, and 12 after liver transplantation. Fifty-seven patients are alive, 13 by virtue of liver replacement, 9 with mild-to-moderate hepatic sequelae, and 35 (28%) with normal to near-normal liver function. Although none is considered "cured," the 35 children are anicteric, have normal growth and development, and participate in full school activities (including contact sports). Average follow-up is 85.8 months (range 1 to 15 years).
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2673083-1094577, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673083-2709292, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673083-2723994, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673083-3965799, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673083-3993060, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673083-4087100, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673083-458541, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673083-6237187, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673083-6481595, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673083-6663406, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673083-7161677, http://linkedlifedata.com/resource/pubmed/commentcorrection/2673083-7241316
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0003-4932
pubmed:author
pubmed:issnType
Print
pubmed:volume
210
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
289-94; discussion 294-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
The surgery of biliary atresia.
pubmed:affiliation
Department of Surgery, University of Colorado School of Medicine, Denver 80262.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't