Linked Life Data

2672965

Source:http://linkedlifedata.com/resource/pubmed/id/2672965

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1989-10-10
pubmed:abstractText
A prominent characteristic of sickle cells is the presence of a subpopulation of severely dehydrated cells. Apart from its effect on the rate and extent of Hb S polymerization at low oxygen tension, dehydration has adverse effects on deformability of oxygenated sickle cells. In general, the degree of deformability defect induced by cellular dehydration measured in vitro depends on the method used to measure deformability. Methods in which the extent or rate of cellular deformation are measured are especially sensitive to intracellular Hb concentration, whereas filtration methods are more sensitive to cell size. Studies of naturally occurring cellular dehydration in red cell disorders other than sickle cell disease have indicated that red cells can tolerate dehydration and a substantial increase in intracellular viscosity much more readily than a loss of deformability that results from loss of surface area or increase in cell volume. Further, the major clinical problems in sickle cell disease, involving occlusion of small vessels, do not correlate with the proportion of poorly deformable, dehydrated cells. Thus, the direct rheologic effects of cellular dehydration in sickle cell disease are probably much less important than the effects of MCHC on the kinetics of Hb S polymerization.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
565
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
284-94
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Mean corpuscular hemoglobin concentration and cell deformability.
pubmed:affiliation
Department of Laboratory Medicine, University of California, San Francisco 94143.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review