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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1989-10-4
|
| pubmed:abstractText |
A number of recent studies have implicated a role of the Ca2+-dependent protein kinase C in the generation of long-term potentiation in the hippocampus. Membrane protein kinase C activity was increased following a high frequency tetanus that produced long-term potentiation; and intracellular injection of protein kinase C caused enhancement of synaptic transmission identical to that occurring during long-term potentiation. Roger Anwyl describes studies using inhibitors and activators of protein kinase C which suggest that a late, nondecremental component of long-term potentiation is dependent on protein kinase C activation, although an early, short-lasting decremental component of long-term potentiation is probably independent of its activity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0165-6147
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
236-9
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1989
|
| pubmed:articleTitle |
Protein kinase C and long-term potentiation in the hippocampus.
|
| pubmed:publicationType |
Journal Article,
Review
|