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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
15
|
| pubmed:dateCreated |
1989-10-12
|
| pubmed:abstractText |
Ascites in patients with cirrhosis of the liver frequently is refractory to diuretic treatment. It was postulated that vasoconstriction of the renal cortex, mediated by activation of the renin-angiotensin-aldosterone-system (RAAS), may be one course of the disturbed sodium- and water-excretion in these patients. We therefore investigated in 14 cirrhotic patients with ascites under constant diuretic treatment the effects of low-dose captopril therapy on urinary sodium- and potassium-excretion, body weight, abdominal girth, serum-sodium, -potassium, creatinine-clearance, plasma-renin-activity (PRA), plasma-aldosterone (PA) and mean arterial pressure (MAP). After a control period of 4 days the patients received 2 x 6.25 mg/d captopril for 5 days and 4 x 6.25 mg/d for further 5 days. Treatment was followed by a second control period without captopril. PRA increased significantly after 2 days of captopril treatment. 2 x 6.25 mg/d captopril induced a significant increase in sodium excretion and a significant decrease of body weight. MAP decreased slightly but significantly without clinical signs of hypotension. 4 x 6.25 mg/d captopril resulted in a further reduction of body weight and a further enhancement of sodium excretion. Three days after withdrawal of captopril sodium output was significantly reduced again. Conclusion: In cirrhotic patients low-dose captopril seems to be efficient in the treatment of ascites resistant to diuretics without causing major side effects.
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| pubmed:language |
ger
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Captopril,
http://linkedlifedata.com/resource/pubmed/chemical/Diuretics,
http://linkedlifedata.com/resource/pubmed/chemical/Furosemide,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrochlorothiazide,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Chloride Symporter Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Spironolactone,
http://linkedlifedata.com/resource/pubmed/chemical/butizide
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0023-2173
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
67
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
774-83
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2671477-Adult,
pubmed-meshheading:2671477-Aged,
pubmed-meshheading:2671477-Ascites,
pubmed-meshheading:2671477-Blood Pressure,
pubmed-meshheading:2671477-Captopril,
pubmed-meshheading:2671477-Diuresis,
pubmed-meshheading:2671477-Diuretics,
pubmed-meshheading:2671477-Dose-Response Relationship, Drug,
pubmed-meshheading:2671477-Drug Therapy, Combination,
pubmed-meshheading:2671477-Female,
pubmed-meshheading:2671477-Furosemide,
pubmed-meshheading:2671477-Glomerular Filtration Rate,
pubmed-meshheading:2671477-Humans,
pubmed-meshheading:2671477-Hydrochlorothiazide,
pubmed-meshheading:2671477-Liver Cirrhosis,
pubmed-meshheading:2671477-Male,
pubmed-meshheading:2671477-Middle Aged,
pubmed-meshheading:2671477-Renin-Angiotensin System,
pubmed-meshheading:2671477-Sodium Chloride Symporter Inhibitors,
pubmed-meshheading:2671477-Spironolactone,
pubmed-meshheading:2671477-Water-Electrolyte Balance
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
[Effect of captopril therapy on sodium and water excretion in patients with liver cirrhosis and ascites].
|
| pubmed:affiliation |
Abteilung Nephrologie, Zentrums Innere Medizin der Medizinischen Hochschule, Hannover.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|