Linked Life Data

2670618

Source:http://linkedlifedata.com/resource/pubmed/id/2670618

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-10-6
pubmed:abstractText
Hyperplasia and dysplasia of the epidermal neuroendocrine cells (i.e., Merkel cells, MC) have been suggested in lesional skin of actinic keratosis and chronic radiation dermatitis. Because several histological types of actinic keratosis exist, we investigated the occurrence of such MC hyperplasia according to each of the histological patterns. Using an immunoperoxidase technique and the cytokeratin monoclonal antibody CAM 5.2, we counted 0.02 CAM 5.2 + cells (i.e., MC)/mm epidermis in normal-appearing perilesional skin; 0.05 MC/mm epidermis in nonhypertrophic actinic keratoses and 4.09 MC/mm epidermis in hypertrophic actinic keratoses. This number was as high as 14.40 MC/mm epidermis when hypertrophic actinic keratoses showed club-like epithelial proliferations. In contrast to normal epidermis, where MC were found isolated within the basal cell layer, MC clustered in these club-like epithelial proliferations as they did in the normal parakeratotic zone of the rabbit lip epithelium. The significance of this selective MC hyperplasia is discussed.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0011-9075
pubmed:author
pubmed:issnType
Print
pubmed:volume
178
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
189-93
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Merkel cell hyperplasia in hypertrophic varieties of actinic keratoses.
pubmed:affiliation
Service de Dermatologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Suisse.
pubmed:publicationType
Journal Article