Linked Life Data

2665736

Source:http://linkedlifedata.com/resource/pubmed/id/2665736

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-8-17
pubmed:abstractText
Hepatic glucagon degradation was studied using recycling perfused livers from 24h fasted rats in the absence of glucose. In comparison with normoxic conditions, a significantly reduced glucagon cleavage was observed within the first 30 min of hypoxic perfusion (acute energy deficiency). On the contrary, glucagon degradation was markedly increased after 30 min. At the same time, increased release of intracellular glucagon-degrading activity occurred. Partial characterization of the degrading activity showed high specificity for glucagon. Both its metal- and thiol-dependent activity and immunological reaction against specific antibodies are characteristic of the insulin-glucagon-proteinase (IGP) of rat liver. These results indicate that a substantial part of the liver-bound glucagon is internalized via an energy-dependent step followed by degradation by IGP.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0232-766X
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
211-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
[Glucagon degradation in the in vitro recycling perfused rat liver during acute energy deficiency].
pubmed:affiliation
Institut für Biochemie, Bereich Medizin, Martin-Luther-Universität Halle-Wittenberg DDR.
pubmed:publicationType
Journal Article, In Vitro, English Abstract