Linked Life Data

2664493

Source:http://linkedlifedata.com/resource/pubmed/id/2664493

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-8-16
pubmed:abstractText
1,1,2-Trichloroethylene (TCE) is a widely used halogenated solvent, produced in hundreds of millions of kg each year for industrial purposes. Occupational and environmental exposure of human populations to TCE has been reported in industrialized areas. Long-term carcinogenicity studies in rodents demonstrate that exposure to high doses of TCE results in the induction of liver and lung tumors in the mouse, and tumors of the kidney and the testis in the rat. An indirect mechanism, based on the stimulation of liver peroxisome proliferation by TCE metabolites, was proposed to explain species differences in TCE hepatocarcinogenicity. Mutagenicity studies indicate that TCE is weakly active both in vitro, where liver microsomes produce electrophilic TCE metabolites, and also in vivo in mouse bone marrow, where high rates of micronuclei, but no structural chromosome aberrations, are found. Among TCE metabolites, trichloroacetic acid was reported to be carcinogenic to mouse liver. Furthermore, both trichloroacetic acid and chloral hydrate were found to be genotoxic in vivo, inducing structural and numerical chromosome abnormalities, respectively.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0027-5107
pubmed:author
pubmed:issnType
Print
pubmed:volume
221
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-37
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Genetic toxicology of 1,1,2-trichloroethylene.
pubmed:affiliation
Istituto Superiore di Sanità, Rome, Italy.
pubmed:publicationType
Journal Article, Review