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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1989-8-1
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pubmed:abstractText |
A complex of new antifungal antibiotics designated karnamicin was isolated from the cultured broth of Saccharothrix aerocolonigenes No. N806-4. Fifteen components have so far been isolated from the complex; the major component karnamicin B2 was identified by X-ray crystallography to be a novel molecule unrelated to known antibiotics. All components of karnamicin exhibited a rather broad spectrum of activity against fungi and yeasts with MICs ranging from 3.1 to 50 micrograms/ml.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0021-8820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
852-68
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2661511-Actinomycetales,
pubmed-meshheading:2661511-Animals,
pubmed-meshheading:2661511-Antifungal Agents,
pubmed-meshheading:2661511-Bacteria,
pubmed-meshheading:2661511-Candida albicans,
pubmed-meshheading:2661511-Candidiasis, Vulvovaginal,
pubmed-meshheading:2661511-Chromatography, Gel,
pubmed-meshheading:2661511-Chromatography, High Pressure Liquid,
pubmed-meshheading:2661511-Female,
pubmed-meshheading:2661511-Fermentation,
pubmed-meshheading:2661511-Fungi,
pubmed-meshheading:2661511-Magnetic Resonance Spectroscopy,
pubmed-meshheading:2661511-Mice,
pubmed-meshheading:2661511-Microscopy, Electron, Scanning,
pubmed-meshheading:2661511-Molecular Structure,
pubmed-meshheading:2661511-Pyridines,
pubmed-meshheading:2661511-Soil Microbiology,
pubmed-meshheading:2661511-Spectrophotometry, Infrared,
pubmed-meshheading:2661511-Spectrophotometry, Ultraviolet,
pubmed-meshheading:2661511-Spores, Bacterial,
pubmed-meshheading:2661511-Thiazoles
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pubmed:year |
1989
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pubmed:articleTitle |
Karnamicin, a complex of new antifungal antibiotics. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties.
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pubmed:affiliation |
Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.
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pubmed:publicationType |
Journal Article
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