Linked Life Data

2655887

Source:http://linkedlifedata.com/resource/pubmed/id/2655887

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-6-29
pubmed:abstractText
We compared the histories of exposure to leukemogens for two groups of patients presenting with myelodysplastic syndrome (MDS) or acute nonlymphocytic leukemia (ANLL). In one group there were 59 patients with an acquired abnormality of chromosomes 5 or 7 in the marrow at time of diagnosis. In the other group there were 39 patients with a normal marrow karyotype at the time of diagnosis. A much higher proportion of the chromosomally abnormal cases had a history of treatment for a previous malignancy (odds ratio = 13.0, p less than 0.01). There was little difference found between the occupational histories of the patients with de novo ANLL with and without cytogenetic abnormalities. An occupational history of exposure to chemicals or metals was more common in males with either a deletion of the long arm of chromosome 7 or with monosomy 7 or monosomy 5 (82.3%) than in males with a normal karyotype (52.1%). The odds ratios did not, however, reach statistical significance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0165-4608
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
261-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Occupational history and involvement of chromosomes 5 and 7 in acute nonlymphocytic leukemia.
pubmed:affiliation
Division of Clinical Genetics, Hospital for Sick Children, Toronto, Ontario, Canada.
pubmed:publicationType
Journal Article, Review