|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1989-6-28
|
|
pubmed:abstractText |
bcr gene rearrangement and c-abl gene expression were analyzed in a patient with Philadelphia chromosome (Ph1)-positive hybrid acute leukemia with simultaneous proliferation of lymphoid and myeloid blasts. These data were compared with those from a patient with chronic myelogenous leukemia (CML) in mixed crisis. The leukemic cells of both patients showed immuno-phenotypic profiles such as non-T, non-B common ALL with some MPO-positive leukemic cells and rearranged JH genes. On analysis of molecular events associated with the Ph1 chromosome, the leukemic cells of a patient with CML in mixed crisis showed bcr rearrangement and an 8.5-kb bcr-abl chimeric mRNA, but those of a patient with Ph1-positive hybrid acute leukemia showed no 8.5-kb bcr-abl mRNA, as previously reported in a number of Ph1-positive acute lymphoblastic leukemia (ALL) cases. These results revealed that the molecular event found in Ph1-positive ALL is not only restricted to lymphoid lineage but may play an important role in the proliferation of the myeloid lineage.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0006-5242
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
58
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
241-6
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:2655744-Adult,
pubmed-meshheading:2655744-Blotting, Southern,
pubmed-meshheading:2655744-Bone Marrow Cells,
pubmed-meshheading:2655744-Female,
pubmed-meshheading:2655744-Gene Expression Regulation,
pubmed-meshheading:2655744-Gene Rearrangement,
pubmed-meshheading:2655744-Genes, Immunoglobulin,
pubmed-meshheading:2655744-Humans,
pubmed-meshheading:2655744-Leukemia, Lymphoid,
pubmed-meshheading:2655744-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:2655744-Male,
pubmed-meshheading:2655744-Middle Aged,
pubmed-meshheading:2655744-Molecular Probe Techniques,
pubmed-meshheading:2655744-Protein-Tyrosine Kinases,
pubmed-meshheading:2655744-Proto-Oncogene Proteins,
pubmed-meshheading:2655744-Proto-Oncogene Proteins c-abl,
pubmed-meshheading:2655744-Proto-Oncogene Proteins c-bcr,
pubmed-meshheading:2655744-RNA, Messenger
|
|
pubmed:year |
1989
|
|
pubmed:articleTitle |
bcr rearrangement and C-abl gene expression in Ph1-positive hybrid acute leukemia with simultaneous proliferation of lymphoid and myeloid blasts.
|
|
pubmed:affiliation |
Third Department of Internal Medicine, School of Medicine, Hokkaido University, Sapporo, Japan.
|
|
pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|
