| pubmed-article:265573 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:265573 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:265573 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:265573 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:265573 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:265573 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:265573 | pubmed:dateCreated | 1977-5-12 | lld:pubmed |
| pubmed-article:265573 | pubmed:abstractText | Changes in extracellular Ca2+ concentration were directly measured in the rat cerebellum, using an ion-selective micropipette. Extracellular K+ was measured simultaneously with a second ion-selective micropipette. The potential reference barrels of the ion electrodes also provided fast field and slow potentials. During repetitive stimulation of the parallel fiber--Purkinje cell cerebellar circuit, extracellular Ca2+ fell to about 80% of base line concentration. During the spreading depression of Leão, extracellular Ca2+ fell to about 10% of base line; decreases of this magnitude also occurred during terminal anoxia. In all cases extracellular K+ increased substantially. These results show that extracellular Ca2+ is modulated during neuronal activity in the central nervous system and that under some conditions the Ca2+ change can be extreme. Given the well-established and antagonistic effects of reduce extracellular Ca2+ on axonal excitability and synaptic transmission, these results suggest that Ca2+ modulation in the brain cell microenvironment may be a significant parameter in the behavior of neuronal ensembles. | lld:pubmed |
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| pubmed-article:265573 | pubmed:language | eng | lld:pubmed |
| pubmed-article:265573 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:265573 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:265573 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:265573 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:265573 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:265573 | pubmed:author | pubmed-author:SteinbergRR | lld:pubmed |
| pubmed-article:265573 | pubmed:author | pubmed-author:NicholsonCC | lld:pubmed |
| pubmed-article:265573 | pubmed:author | pubmed-author:BruggencateG... | lld:pubmed |
| pubmed-article:265573 | pubmed:author | pubmed-author:StöckleHH | lld:pubmed |
| pubmed-article:265573 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:265573 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:265573 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:265573 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:265573 | pubmed:pagination | 1287-90 | lld:pubmed |
| pubmed-article:265573 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:265573 | pubmed:year | 1977 | lld:pubmed |
| pubmed-article:265573 | pubmed:articleTitle | Calcium modulation in brain extracellular microenvironment demonstrated with ion-selective micropipette. | lld:pubmed |
| pubmed-article:265573 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:265573 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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