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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1977-5-12
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pubmed:abstractText |
Changes in extracellular Ca2+ concentration were directly measured in the rat cerebellum, using an ion-selective micropipette. Extracellular K+ was measured simultaneously with a second ion-selective micropipette. The potential reference barrels of the ion electrodes also provided fast field and slow potentials. During repetitive stimulation of the parallel fiber--Purkinje cell cerebellar circuit, extracellular Ca2+ fell to about 80% of base line concentration. During the spreading depression of Leão, extracellular Ca2+ fell to about 10% of base line; decreases of this magnitude also occurred during terminal anoxia. In all cases extracellular K+ increased substantially. These results show that extracellular Ca2+ is modulated during neuronal activity in the central nervous system and that under some conditions the Ca2+ change can be extreme. Given the well-established and antagonistic effects of reduce extracellular Ca2+ on axonal excitability and synaptic transmission, these results suggest that Ca2+ modulation in the brain cell microenvironment may be a significant parameter in the behavior of neuronal ensembles.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-1064869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-1065905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-1083528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-1139318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-1175022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-1177091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-13295838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-13449874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-13642064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-13892798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-235124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-237277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-4153563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-4472242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-4705519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-5025649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-5499746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-5542207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-816678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-982036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/265573-994042
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1287-90
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:265573-Animals,
pubmed-meshheading:265573-Anoxia,
pubmed-meshheading:265573-Calcium,
pubmed-meshheading:265573-Cerebellum,
pubmed-meshheading:265573-Cortical Spreading Depression,
pubmed-meshheading:265573-Electric Stimulation,
pubmed-meshheading:265573-Extracellular Space,
pubmed-meshheading:265573-Microelectrodes,
pubmed-meshheading:265573-Neurons,
pubmed-meshheading:265573-Potassium,
pubmed-meshheading:265573-Purkinje Cells,
pubmed-meshheading:265573-Rats
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pubmed:year |
1977
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pubmed:articleTitle |
Calcium modulation in brain extracellular microenvironment demonstrated with ion-selective micropipette.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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