| pubmed-article:2653409 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2653409 | lifeskim:mentions | umls-concept:C0035648 | lld:lifeskim |
| pubmed-article:2653409 | lifeskim:mentions | umls-concept:C0005961 | lld:lifeskim |
| pubmed-article:2653409 | lifeskim:mentions | umls-concept:C0002874 | lld:lifeskim |
| pubmed-article:2653409 | lifeskim:mentions | umls-concept:C0206061 | lld:lifeskim |
| pubmed-article:2653409 | lifeskim:mentions | umls-concept:C0205082 | lld:lifeskim |
| pubmed-article:2653409 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2653409 | pubmed:dateCreated | 1989-6-19 | lld:pubmed |
| pubmed-article:2653409 | pubmed:abstractText | Data from 547 patients with aplastic anaemia who received bone marrow transplants from HLA-identical siblings were analysed to determine factors associated with the risk of interstitial pneumonia (IPn). IPn developed in 92 patients (17%). 37% of cases were associated with cytomegalovirus infection and 22% with other organisms; in 41% of cases no organism was identified. The case fatality rate was 64%; the mortality rate due to IPn was 11%. In multivariate analysis, four factors were associated with an increased probability of interstitial pneumonia: use of methotrexate rather than cyclosporine after transplantation (relative risk, 2.8; P less than 0.0008); occurrence of moderate to severe acute graft-versus-host disease (relative risk, 2.2; P less than 0.002); inclusion of total body radiation in the pretransplant preparative regimen (relative risk 2.2, P less than 0.004); and patient age greater than 20 (relative risk 1.7, P less than 0.002). The probability of IPn ranged from 4% for patients with none of these adverse risk factors to 51% (relative risk of 13.4) for patients with all four. The incidence of IPn decreased significantly between 1978 and 1985, paralleling a decrease in the use of total body radiation pretransplant for immune suppression and methotrexate post-transplant for prophylaxis against graft-versus-host disease. | lld:pubmed |
| pubmed-article:2653409 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2653409 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2653409 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2653409 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2653409 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2653409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2653409 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2653409 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2653409 | pubmed:issn | 0007-1048 | lld:pubmed |
| pubmed-article:2653409 | pubmed:author | pubmed-author:van BekkumD... | lld:pubmed |
| pubmed-article:2653409 | pubmed:author | pubmed-author:GaleR PRP | lld:pubmed |
| pubmed-article:2653409 | pubmed:author | pubmed-author:BortinM MMM | lld:pubmed |
| pubmed-article:2653409 | pubmed:author | pubmed-author:RimmA AAA | lld:pubmed |
| pubmed-article:2653409 | pubmed:author | pubmed-author:WeinerR SRS | lld:pubmed |
| pubmed-article:2653409 | pubmed:author | pubmed-author:DickeK AKA | lld:pubmed |
| pubmed-article:2653409 | pubmed:author | pubmed-author:RozmanCC | lld:pubmed |
| pubmed-article:2653409 | pubmed:author | pubmed-author:RamsayN KNK | lld:pubmed |
| pubmed-article:2653409 | pubmed:author | pubmed-author:MasaokaTT | lld:pubmed |
| pubmed-article:2653409 | pubmed:author | pubmed-author:HorowitzM MMM | lld:pubmed |
| pubmed-article:2653409 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2653409 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:2653409 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2653409 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2653409 | pubmed:pagination | 535-43 | lld:pubmed |
| pubmed-article:2653409 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2653409 | pubmed:meshHeading | pubmed-meshheading:2653409-... | lld:pubmed |
| pubmed-article:2653409 | pubmed:meshHeading | pubmed-meshheading:2653409-... | lld:pubmed |
| pubmed-article:2653409 | pubmed:meshHeading | pubmed-meshheading:2653409-... | lld:pubmed |
| pubmed-article:2653409 | pubmed:meshHeading | pubmed-meshheading:2653409-... | lld:pubmed |
| pubmed-article:2653409 | pubmed:meshHeading | pubmed-meshheading:2653409-... | lld:pubmed |
| pubmed-article:2653409 | pubmed:meshHeading | pubmed-meshheading:2653409-... | lld:pubmed |
| pubmed-article:2653409 | pubmed:meshHeading | pubmed-meshheading:2653409-... | lld:pubmed |
| pubmed-article:2653409 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2653409 | pubmed:articleTitle | Risk factors for interstitial pneumonia following bone marrow transplantation for severe aplastic anaemia. | lld:pubmed |
| pubmed-article:2653409 | pubmed:affiliation | Department of Medicine, Medical College of Wisconsin, Milwaukee 53226. | lld:pubmed |
| pubmed-article:2653409 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2653409 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2653409 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2653409 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2653409 | lld:pubmed |
