Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-5-26
pubmed:abstractText
To assess the efficacy of ciprofloxacin in neutropenic patients, we conducted a randomized prospective trial comparing the combination of ciprofloxacin and netilmicin against piperacillin plus netilmicin as an empiric treatment of fever in cancer patients with neutropenia. Of 214 evaluable episodes, 115 and 99 were randomly assigned to the ciprofloxacin and the piperacillin arms, respectively. The overall response rates were very similar (59 and 62% for the ciprofloxacin and piperacillin arms, respectively). The response for the gram-positive bacteremias was almost identical (around 40%); this low response was due in part to an outbreak of infection by a multiply resistant strain of Staphylococcus epidermidis (for which the ciprofloxacin MIC was greater than or equal to 128 micrograms/ml) which occurred during the second half of the trial. Among gram-negative bacteremias, 9 of 11 infections (82%) responded to the ciprofloxacin combination compared with 3 of 7 (43%) that responded to the piperacillin combination (P = 0.23). The incidences of persistent, profound neutropenia were comparable in both treatments, but the susceptibility of the gram-negative organism to ciprofloxacin and netilmicin was significantly higher than was susceptibility to the other combination. Ciprofloxacin was well tolerated, and patients were able to convert from intravenous to oral therapy in 64 of 115 episodes.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
87-91
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:2653217-Administration, Oral, pubmed-meshheading:2653217-Adolescent, pubmed-meshheading:2653217-Adult, pubmed-meshheading:2653217-Aged, pubmed-meshheading:2653217-Agranulocytosis, pubmed-meshheading:2653217-Bacterial Infections, pubmed-meshheading:2653217-Bone Marrow Transplantation, pubmed-meshheading:2653217-Ciprofloxacin, pubmed-meshheading:2653217-Drug Therapy, Combination, pubmed-meshheading:2653217-Female, pubmed-meshheading:2653217-Fever, pubmed-meshheading:2653217-Humans, pubmed-meshheading:2653217-Infusions, Intravenous, pubmed-meshheading:2653217-Injections, Intravenous, pubmed-meshheading:2653217-Leukemia, pubmed-meshheading:2653217-Lymphoma, pubmed-meshheading:2653217-Male, pubmed-meshheading:2653217-Middle Aged, pubmed-meshheading:2653217-Netilmicin, pubmed-meshheading:2653217-Neutropenia, pubmed-meshheading:2653217-Piperacillin, pubmed-meshheading:2653217-Prospective Studies, pubmed-meshheading:2653217-Random Allocation
pubmed:year
1989
pubmed:articleTitle
Randomized trial comparing ciprofloxacin plus netilmicin versus piperacillin plus netilmicin for empiric treatment of fever in neutropenic patients.
pubmed:affiliation
Department of Medical Oncology, Christie Hospital, Manchester, United Kingdom.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't