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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1989-6-8
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pubmed:abstractText |
Dimac with silver sulfadiazine (Dimac-SSD), a new silver sulfadiazine delivery system, was evaluated prospectively in a multicenter study for the treatment of outpatient burn injuries. The goal of this study was to evaluate the effect of Dimac-SSD on the microbiology of the burn wounds and to quantitate its clinical safety and efficacy. A total of 197 patients were evaluated. Eight (4%) of these patients did not complete the study. Six patients withdrew because of local discomfort caused by the Dimac-SSD and two patients were terminated because of technical problems. The mean +/- SD duration of treatment with Dimac-SSD was 12 +/- 8.5 days, during which time the mean number of dressing changes was 2.9 per patient. During treatment with Dimac-SSD, the burn wound bacterial flora remained stable and overgrowth with Pseudomonas species or Gram-negative bacilli did not occur. Only four (2%) patients developed clinical infections; thus the Dimac-SSD appeared to have good antimicrobial effectiveness. This dressing was not associated with any organ system or metabolic side-effects and patient discomfort during application and removal was minimal. Thus this new delivery system for silver sulfadiazine was associated with excellent wound healing, a low incidence of wound infections, reduced frequency for dressing changes, and excellent patient compliance.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-5282
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
430-4
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2651681-Acrylates,
pubmed-meshheading:2651681-Administration, Cutaneous,
pubmed-meshheading:2651681-Adolescent,
pubmed-meshheading:2651681-Adult,
pubmed-meshheading:2651681-Aged,
pubmed-meshheading:2651681-Aged, 80 and over,
pubmed-meshheading:2651681-Ambulatory Care,
pubmed-meshheading:2651681-Bandages,
pubmed-meshheading:2651681-Burns,
pubmed-meshheading:2651681-Child,
pubmed-meshheading:2651681-Child, Preschool,
pubmed-meshheading:2651681-Dimethyl Sulfoxide,
pubmed-meshheading:2651681-Drug Combinations,
pubmed-meshheading:2651681-Evaluation Studies as Topic,
pubmed-meshheading:2651681-Female,
pubmed-meshheading:2651681-Humans,
pubmed-meshheading:2651681-Male,
pubmed-meshheading:2651681-Methacrylates,
pubmed-meshheading:2651681-Middle Aged,
pubmed-meshheading:2651681-Multicenter Studies as Topic,
pubmed-meshheading:2651681-Polyethylene Glycols,
pubmed-meshheading:2651681-Prospective Studies,
pubmed-meshheading:2651681-Silver,
pubmed-meshheading:2651681-Silver Sulfadiazine,
pubmed-meshheading:2651681-Sulfadiazine,
pubmed-meshheading:2651681-Wound Infection
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pubmed:year |
1989
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pubmed:articleTitle |
Results of a multicenter outpatient burn study on the safety and efficacy of Dimac-SSD, a new delivery system for silver sulfadiazine.
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pubmed:affiliation |
Department of Surgery, LSUMC, School of Medicine, Shreveport 71130-3932.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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