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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1989-6-2
|
| pubmed:abstractText |
To examine the effect of hypobaric hypoxia on plasma lipid profiles, fasting blood samples were collected from six men (21-31 yr) at 760 Torr and periodically during a 40-day exposure to decreasing barometric pressure culminating in a final ambient pressure of 282 Torr. Preascent plasma total cholesterol concentration ([TC]) was decreased by 25% after the 40-day exposure (P less than 0.01). High-density lipoprotein concentrations ([HDL-C]) decreased 32% (P less than 0.001) with no alteration in the TC-to-HDL-C weight ratio. Plasma triglyceride concentration increased twofold during this period (P less than 0.01). There were no significant differences in fasting plasma free fatty acid concentrations or free fatty acid-to-albumin molar ratio throughout the study. Fasting plasma insulin levels were increased approximately twofold with no significant changes in glucagon concentration or the insulin-to-glucagon molar ratio. Plasma norepinephrine concentrations were increased threefold on reaching 282 Torr (P less than 0.01), with no significant changes in plasma epinephrine concentrations. Mean energy intake (kcal/day) decreased 42%, whereas mean body weights decreased by 8.9 +/- 0.8% (P less than 0.01) with exposure. Increased concentrations of insulin may lead to increased hepatic production of triglyceride-rich lipoproteins, thus eliciting metabolic changes independent of weight loss and dietary intake.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Nonesterified,
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon,
http://linkedlifedata.com/resource/pubmed/chemical/Glycerol,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
8750-7587
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
66
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1430-5
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2651390-Adult,
pubmed-meshheading:2651390-Altitude,
pubmed-meshheading:2651390-Anoxia,
pubmed-meshheading:2651390-Blood Glucose,
pubmed-meshheading:2651390-Body Composition,
pubmed-meshheading:2651390-Fasting,
pubmed-meshheading:2651390-Fatty Acids, Nonesterified,
pubmed-meshheading:2651390-Glucagon,
pubmed-meshheading:2651390-Glycerol,
pubmed-meshheading:2651390-Growth Hormone,
pubmed-meshheading:2651390-Hormones,
pubmed-meshheading:2651390-Humans,
pubmed-meshheading:2651390-Insulin,
pubmed-meshheading:2651390-Lipids,
pubmed-meshheading:2651390-Male,
pubmed-meshheading:2651390-Norepinephrine,
pubmed-meshheading:2651390-Nutritional Status,
pubmed-meshheading:2651390-Oxygen Consumption,
pubmed-meshheading:2651390-Reference Values,
pubmed-meshheading:2651390-Triglycerides,
pubmed-meshheading:2651390-Weight Loss
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Operation Everest II: plasma lipid and hormonal responses during a simulated ascent of Mt. Everest.
|
| pubmed:affiliation |
US Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|