Linked Life Data

2649964

Source:http://linkedlifedata.com/resource/pubmed/id/2649964

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-5-12
pubmed:abstractText
The diagnostic value of antibody detection by indirect hemagglutination (IHA), indirect immunofluorescence (IFA), and counterimmunoelectrophoresis (CIE) and of Candida albicans mannan antigen detection by latex agglutination was studied in 36 cases of systemic candidiasis in heroin addicts. The IHA and IFA techniques were highly sensitive (97% and 91%, respectively), but their specificity was low (60% and 50%). When a titer of greater than or equal to 1:2,560 was used as a criterion for IHA positivity, the specificity of the test rose to 87%, with sensitivity at 75%. CIE had a high degree of specificity (96%) but a low degree of sensitivity (58%). A good correlation was found between clinical evolution of infection and serologic data. Two of 12 patients who could be followed for 9-16 months had a rise in antibody titer detected either by IFA or by IHA and CIE. These two patients had a persistent chondrocostal tumor and C. albicans endocarditis, respectively. All of the other patients, who were cured, had a decrease in titer detected by IHA and IFA and had negative CIE results at the end of follow-up. Serum mannan antigen was not found in any case. The detection of antibody to C. albicans may be useful for diagnosis and follow-up of such patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0162-0886
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
310-5
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Diagnostic value of serum antibody and antigen detection in heroin addicts with systemic candidiasis.
pubmed:affiliation
Infectious Diseases Unit, Hospital Clinic i Provincial; Barcelona, Spain.
pubmed:publicationType
Journal Article