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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1989-5-24
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pubmed:abstractText |
Liver tumors arise in rats fed a choline-devoid diet without added carcinogens. We found amplification of the c-myc gene in 13/13 of these tumors. The amplification ranged from 2- to 70-fold and was accompanied by an increase in c-myc gene expression. Amplification of c-myc was larger in tumors of rats fed a choline-devoid diet followed by a choline-supplemented diet than in tumors from animals fed a choline-devoid diet exclusively. In the former animals, low levels of c-myc gene amplification were also detected in nontumorous regions of tumor-bearing livers. The choline-devoid diet provides an in vivo experimental model for the induction of gene amplification in the rat liver. In this setting, amplification of the c-myc gene may be an early and critical event in carcinogenesis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-2436615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-2859112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-3010283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-3017342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-3028245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-3030308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-3034414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-3099168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-3099282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-3306601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-3314528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-3338109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-3510430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-3516391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-3581425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-3629242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-3731384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-3802390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-3978602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-6298772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-6312838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-6317218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-6462227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-6468836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-6488458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-6646229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-6721844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2649891-7111024
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2703-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2649891-Animals,
pubmed-meshheading:2649891-Blotting, Southern,
pubmed-meshheading:2649891-Cell Division,
pubmed-meshheading:2649891-Choline Deficiency,
pubmed-meshheading:2649891-DNA, Neoplasm,
pubmed-meshheading:2649891-Gene Amplification,
pubmed-meshheading:2649891-Gene Expression Regulation,
pubmed-meshheading:2649891-Liver,
pubmed-meshheading:2649891-Liver Neoplasms,
pubmed-meshheading:2649891-Liver Neoplasms, Experimental,
pubmed-meshheading:2649891-Proto-Oncogene Proteins,
pubmed-meshheading:2649891-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:2649891-RNA, Messenger,
pubmed-meshheading:2649891-RNA, Neoplasm
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pubmed:year |
1989
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pubmed:articleTitle |
c-myc gene amplification during hepatocarcinogenesis by a choline-devoid diet.
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pubmed:affiliation |
Department of Pathology, University of Pittsburgh, PA 15261.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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