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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1989-5-10
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pubmed:abstractText |
One hundred and twenty nine de novo patients with idiopathic Parkinson's disease are being followed over a 5 year period in a double-blind multicentre study comparing low-dose bromocriptine (less than 30 mg/day) with low-dose levodopa-carbidopa (less than 600/150 mg/day). Sixty six patients have been randomised to bromocriptine and 63 patients to levodopa-carbidopa. Improvement has been greater in the levodopa-carbidopa group than in the bromocriptine group. Involuntary movements have so far only occurred in patients on levodopa-carbidopa, the incidence being much lower than is usually described with conventional doses. Mild, end-of-dose failure has occurred in both treatment groups; however, no patient has developed the "on-off" phenomenon. Low-dose levodopa-carbidopa appears to be a more effective anti-Parkinsonian treatment than low-dose bromocriptine but more prone to cause dyskinesia.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-13876261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-3511405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-37066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-3762973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-3978651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-3984685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-4004603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-444100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-5122157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-55599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-572493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-6069607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-6540397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-6713316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-6713321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-6858771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-6858781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-7013595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-7201089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-7465763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-772175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-817698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2647907-839864
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-3050
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
324-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2647907-Adult,
pubmed-meshheading:2647907-Aged,
pubmed-meshheading:2647907-Bromocriptine,
pubmed-meshheading:2647907-Carbidopa,
pubmed-meshheading:2647907-Clinical Trials as Topic,
pubmed-meshheading:2647907-Dose-Response Relationship, Drug,
pubmed-meshheading:2647907-Drug Administration Schedule,
pubmed-meshheading:2647907-Drug Therapy, Combination,
pubmed-meshheading:2647907-Female,
pubmed-meshheading:2647907-Follow-Up Studies,
pubmed-meshheading:2647907-Humans,
pubmed-meshheading:2647907-Levodopa,
pubmed-meshheading:2647907-Male,
pubmed-meshheading:2647907-Middle Aged,
pubmed-meshheading:2647907-Parkinson Disease,
pubmed-meshheading:2647907-Random Allocation
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pubmed:year |
1989
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pubmed:articleTitle |
The Sydney Multicentre Study of Parkinson's disease: a report on the first 3 years.
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pubmed:affiliation |
Neurology Unit, Westmead Hospital, Wentworthville, NSW, Australia.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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