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pubmed-article:2647469pubmed:abstractTextThe in vivo administration of sodium orthovanadate stimulated the incorporation of [14C]glucose into [14C] glycogen, in a dose- and time-dependent manner, in mouse diaphragm. Activation of diaphragm insulin receptor was measured by exogenous tyrosine kinase activity and an antibody that recognizes a conformational change in the receptor beta-subunit upon autophosphorylation. Neither method detected insulin receptor activation by in vivo vanadate administration, suggesting that vanadate's insulin-mimetic effect on mouse diaphragm glycogenesis occurs at a site distal to the insulin receptor.lld:pubmed
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pubmed-article:2647469pubmed:articleTitleThe insulin-mimetic effect of vanadate is not correlated with insulin receptor tyrosine kinase activity nor phosphorylation in mouse diaphragm in vivo.lld:pubmed
pubmed-article:2647469pubmed:affiliationDepartment of Biochemical Endocrinology, Merck, Sharp, and Dohme Research Laboratories, Rahway, New Jerey 07065.lld:pubmed
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