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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1989-5-3
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pubmed:abstractText |
The in vivo administration of sodium orthovanadate stimulated the incorporation of [14C]glucose into [14C] glycogen, in a dose- and time-dependent manner, in mouse diaphragm. Activation of diaphragm insulin receptor was measured by exogenous tyrosine kinase activity and an antibody that recognizes a conformational change in the receptor beta-subunit upon autophosphorylation. Neither method detected insulin receptor activation by in vivo vanadate administration, suggesting that vanadate's insulin-mimetic effect on mouse diaphragm glycogenesis occurs at a site distal to the insulin receptor.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0013-7227
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1918-24
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2647469-Animals,
pubmed-meshheading:2647469-Diaphragm,
pubmed-meshheading:2647469-Glycogen,
pubmed-meshheading:2647469-Insulin,
pubmed-meshheading:2647469-Mice,
pubmed-meshheading:2647469-Muscles,
pubmed-meshheading:2647469-Phosphorylation,
pubmed-meshheading:2647469-Precipitin Tests,
pubmed-meshheading:2647469-Protein-Tyrosine Kinases,
pubmed-meshheading:2647469-Receptor, Insulin,
pubmed-meshheading:2647469-Vanadates
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pubmed:year |
1989
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pubmed:articleTitle |
The insulin-mimetic effect of vanadate is not correlated with insulin receptor tyrosine kinase activity nor phosphorylation in mouse diaphragm in vivo.
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pubmed:affiliation |
Department of Biochemical Endocrinology, Merck, Sharp, and Dohme Research Laboratories, Rahway, New Jerey 07065.
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pubmed:publicationType |
Journal Article
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