Linked Life Data

2647447

Source:http://linkedlifedata.com/resource/pubmed/id/2647447

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-5-1
pubmed:abstractText
It is well known that in diabetes mellitus the early phase insulin release response to glucose becomes blunted. Besides, autonomic neuropathy develops frequently. The autonomic nerve function is related to insulin release in normal subjects. Therefore, in the present study the autonomic function was investigated in different degrees of the early phase insulin release response to glucose loading in borderline diabetes mellitus (B-DM) as well as the early stage of diabetes mellitus (E-DM). In our study the pupillary light reflex seemed to be more sensitive for the detection of autonomic neuropathy than the cardiac beat-to-beat variation in B-DM and E-DM. The light reflex, therefore, was used and the following results were obtained. (1) Autonomic neuropathy was detected even in B-DM, though it was slighter than in E-DM. (2) The parasympathetic nerve appeared to be impaired more than the sympathetic in B-DM and this was especially the case in subjects with relatively good insulin release response. Therefore, the suppression of the early phase insulin release in B-DM may be caused by this autonomic neuropathy already present. (3) In B-DM with reduced insulin release autonomic neuropathy seemed to be more advanced and it became more remarkable in E-DM. Particularly the sympathetic abnormality was loaded in this regard. These observations suggest that it is necessary to consider an involvement of autonomic nerve dysfunction for the understanding of the pathogenesis of B-DM.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0168-8227
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
89-94
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Pupillary light reflex in borderline diabetes mellitus.
pubmed:affiliation
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
pubmed:publicationType
Journal Article