Linked Life Data

2647304

Source:http://linkedlifedata.com/resource/pubmed/id/2647304

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1989-5-9
pubmed:abstractText
Two newly characterized structural families of adhesion molecules, in concert with known members of the integrin and immunoglobulin supergene families, mediate the interaction of circulating lymphoid cells with the vessel wall. The Hermes/CD44 antigen family participates in attachment to multiple vascular beds and consists of a common polypeptide core showing amino-terminal homology to cartilage link proteins. In contrast, the node-specific homing receptor Mel-14 consists of substructures homologous to calcium-dependent lectins, EGF, and complement binding proteins. The sequence of Mel-14 provides structural support for the hypothesis that lectin-carbohydrate interactions mediate physiologically significant adhesion events in the course of lymphocyte recirculation. The discovery of a similar structure in ELAM-1 and GMP-140 extends the reach of this family to other leukocyte and platelet interactions with the vessel wall.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
907-10
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Adhesion molecules controlling lymphocyte migration.
pubmed:affiliation
Department of Pathology University of Michigan, Ann Arbor 48109-0602.
pubmed:publicationType
Journal Article, Review